Simulation of Cancer Drug Carrying NanoCapsules Benefiting from dro‎plet NanoFluidic Technologies

9/17/2023 12:00:00 AM

Microfluidic droplet-based devices have attracted vast attention in various applications such as lab-on-a-chip and also preparing nanoparticles, drug delivery, tissue engineering, cell culture, and biosensors. In this thesis, a computing fluid dynamic model developed in COMSOL Multiphysics for a deep understanding of droplet’s shape and dimension in a focal microchannel flow using two non-Newtonian incompressible fluids. Chitosan solutions with different concentrations was used as separated fluid and vegetable oil as continuous fluid. Effect of manipulating the volumetric rate of inlet fluids flow and change in dynamic characteristics of the separated fluid in size, shape, and process of droplet generation was investigated. Considering different situations, 192 simulation tests performed for full coverage of the effect of inlet fluid velocities and separated fluid concentrations on the final results. Ultimately, using the particle tracing module, simulation of release and loading of nanoparticle drug models in the separated fluid was discussed.