چكيده به لاتين
Hyperthermia is used in combination with other methods such as chemotherapy and radiotherapy to treat cancer. Homogeneous temperature, temperature control and temperature monitoring are major challenges to having a good therapeutic hyperthermia. In the present hyperthermia group, we have tried to use each challenge for a specific type of hyperthermia according to the conditions and facilities. Ultrasound device for non-invasive temperature monitoring, microwave hyperthermia due to suitable conditions and sufficient equipment abroad to control temperature and nanoparticle hyperthermia due to localization of this method have been used for temperature homogenization. The last two are specifically mentioned in this project. The main purpose of the project is to investigate the injection velocity parameter. It should be noted that this parameter, in addition to being engineering and has a direct effect on the homogenization and improvement of hyperthermia, especially nanoparticle hyperthermia, has received little attention from researchers and physicians. Also the nanoparticle concentration parameter by which the biological part and materials of the project can be practically controlled. Also, a very important point in the process of hyperthermia is that the temperature should not go below a limit and above a limit, so in this project, we have tried to control the temperature, which has been unknown due to many problems until recent years, as much as possible. Can be done. The present project consists of three main parts. experimental part, modeling and simulation part and control part. First, in the experimental part, new nanoparticles with good therapeutic and magnetic properties were synthesized, then temperature increase and biocompatibility were examined, and in-vitro and in-vivo tests were performed on mice with breast cancer to evaluate the mentioned parameters. Finally, various parameters were evaluated and optimized during the test process, and for the important parameters, the optimal MNPs concentration of 1 mg / ml and the injection velocity of 10 μl / min were selected as the most appropriate values. Then, some input and output values of hyperthermia experiments were considered as modeling and simulation inputs, and after their validation, modeling was used to use a wider range of experiments to find the optimal treatment process. For modeling, attempts were made to avoid simplifications as much as possible. For this purpose, the real model of the tumor with the capillaries was used and also tried to use the two-way coupling of fluid flow, mass transfer and heat transfer environments to obtain the results. Finally, due to the availability of facilities in the hyperthermia center of Erasmus Hospital at the time of the study opportunity, a user-friendly set-up with control software was designed and built to keep the temperature constant in microwave hyperthermia to control the temperature inside the rat liver. The ultimate goal is to transfer knowledge for use in nanoparticle hyperthermia and for clinical purposes. Finally, an optimal treatment protocol from the studies conducted in the project is proposed for research and treatment purposes.
