چكيده به لاتين
Cancer is one of the leading causes of death worldwide. Cytotoxic drugs are used to treat cancer, which have many side effects on the patient and kill both healthy and cancer cells. Different morphologies of gold nanoparticles have many applications in the treatment of cancer due to their superficial plasmon properties and biocompatibility in targeted drug delivery. Rod-shaped gold nanoparticles are widely used in photothermal therapy and drug release control. Polyvinyl alcohol is one of the polymers that due to its biocompatibility, good stability against high temperatures, sensitivity to acidic environment and temperature, has a high potential for targeted delivery and release of drug loaded between its chains. Biomolecules, such as antibodies, are compounds that can cause drug delivery systems to deliver loaded drugs purposefully. In this study, a drug delivery system with the ability to control the targeted release of doxorubicin as an anticancer drug has been designed. Various physicochemical analyzes were used to determine the characteristics of drug delivery systems made of rod-shaped gold nanoparticles, modified polyvinyl alcohol, doxorubicin loaded between polyvinyl alcohol chains, and antibodies for targeted delivery of the loaded drug. In order to control the release of the drug, gold nanoparticles with rod-shaped morphology were used, and also for the targeted delivery of doxorubicin drug loaded in the constructed nanocarrier, which has the ability to kill breast cancer cells, Herceptin antibody was used. In order to confirm the core-shell structure of the prepared nanocarrier, various physicochemical analyzes such as infrared spectroscopy, X-ray diffraction analysis, contact angle analysis, dynamic light scattering analysis, transmission electron microscopy, and scanning electron microscopy were used. Visible-ultraviolet analysis was also used to evaluate the controlled release of doxorubicin loaded in its structure.
