شميمه شمسي

Magnetic nanoparticles have shown an effective application in medicine to improve various types of diseases such as osteoporosis, trauma, and neurodegenerative disorders. But due to their toxicity and non-degradability, their use in therapeutic purposes is limited. Hence, their surface modification is often needed for greater biocompatibility. Since hydroxyapatite is a biocompatible and biodegradable material, using it along with magnetic nanoparticles can minimize the concerns related to the toxicity of these particles. In this research, iron oxide-zinc doped hydroxyapatite core-shell magnetic nanocomposite was synthesized with a new approach based on hydrothermal method at 200°C. Nanocomposite’s hydroxyapatite shell was extracted from Cerastoderma shells as a bio-waste material, which is not only rich in calcium, but also provides the possibility of green and ecofriendly synthesis. Also, the doped zinc oxide in this shell led to antibacterial properties induction in the nanocomposite. According to the results obtained from X-ray diffraction (XRD) analysis, the presence of magnetite and hydroxyl-apatite phase in the nanocomposite was confirmed. Fourier transform infrared spectroscopy (FTIR) confirmed the presence of common bonds and functional groups in iron oxide and hydroxyapatite compounds. According to the results of vibrating sample magnetometer (VSM), the nanocomposite showed typical superparamagnetic behavior. Analysis with field emission scanning electron microscope (FESEM) showed that the nanocomposite has a spherical shape, good particle size and ZnO distribution. Also, the photos obtained from the transmission electron microscopy (TEM) showed the quasi-spherical shape of the nanocomposite. And the presence of zinc oxide in the hydroxyapatite shell led to the relatively suitable antibacterial properties in the nanocomposite, which were eva‎luated by the minimum inhibitory-bactericidal concentration (MIC-MBC) test.

هايپرترميا , زباله هاي زيستي , نانوذرات هسته-پوسته , مواد مغناطيسي , صدف هاي سراستودرما

hyperthermia , bio-wastes , core-shell nanoparticles , magnetic materials , Cerasroderma seashells

Shamime Shamsi

Dr. Alireza Eivani - Dr. Rahim Naghizadeh