چكيده به لاتين
In this research, electromembrane extraction of three acidic drugs, including Aspirin, Naproxen, and Ibuprofen, was performed in a microfluidic chip made of silicon and polymethyl methacrylate to investigate the effect of pore size, thickness, and surface modification of polyvinylidene fluoride membranes. In order to investigate the effect of pore size, three types of membranes with different average pore sizes were synthesized and examined. Then, the effect of the membrane thickness was assessed. The membrane with the optimal pore size was synthesized with three thicknesses of 30, 51, and 75 micrometers, and the best result was obtained at the thickness of 51 micrometers. Finally, to modify the membrane's surface properties, two membrane samples were modified using a chemical method using octadecyl trichlorosilane. The results show an increase in the extraction of the three drugs and improved performance as a result of the surface modification. In order to quantitatively and qualitatively examine the morphology and surface modification of the membranes, Fourier Transform Infrared Spectroscopy, Energy Dispersive X-ray Spectroscopy, Field Emission Scanning Electron Microscope, Atomic Force Microscopy, and contact angle tests were performed. In the process of drug extraction, voltage, donor phase flow rate, and acceptor phase composition were considered quantitative parameters, and the membrane type was used as a qualitative parameter affecting the extraction. The optimization and design of the experiments were done using the response surface methodology. At the optimal conditions, pre-concentration factors of 32.86, 23.85, and 21.6 were obtained for aspirin, naproxen, and ibuprofen, respectively.
