انا زماني

Human involvement with fungal diseases has increased exponentially in recent years. Fungal infections can be fatal if left untreated, especially for residents of tropical countries where climate plays a key role in fungal growth. Metal-organic frameworks are synthetic polymer composite materials that consist of metal ions or metal clusters and an organic linker that connects the structure together. Porosity is the most important key feature of metal-organic frameworks. In this research, preparing and determining the characteristics of drug-carrying nanoparticles, made of metal-organic frameworks coating (porous structure), along with voriconazole (as an antifungal agent) and silver nanoparticles in polyvinyl alcohol substrate and The amino acid arginine penetrating the cell to increase the antifungal properties of the nanocarrier was well performed and confirmed by various analysis methods. At first, the basic metal-organic framework was synthesized (Bio-MOF-11) and voriconazole drug was loaded in Bio-MOF-11, then silver nanoparticles were used on polyvinyl alcohol substrate functionalized with guanidine to increase the antifungal properties. In the next step, the properties and structural characteristics of the nanocarrier were eva‎luated. Then, the amount of drug released from the nanocarrier was investigated.

چارچوب هاي فلز-آلي , نانوذرات نقره , آمينواسيد آرژنين , وريكونازول , رهايش كنترل شده

metal-organic frameworks , Silver nanoparticles , amino acid arginine , Voriconazole , controlled release

Ana Zamani

Dr. Ali Maleki