علي امامي

Today, cancer is one of the leading causes of death in the world, and to deal with this disease, combined treatment methods with the use of nanocarriers have been investigated. Accordingly, in this study, niosomal nanocarriers loaded with erlotinib and curcumin drugs were designed and eva‎luated. The performance of the designed nanosystems was eva‎luated on A549 and HDF cell lines. To check the properties of the designed nanopatterns, drug-loaded niosomes and drug-free niosomes were prepared and analyzed. First, the dynamic light scattering test was performed to determine the particle size, and in this test, the average size of drug-free niosomes and drug-loaded niosomes was determined to be 128.6 and 158.4 nm, respectively. Zeta potential test was performed to check the surface charge of niosomes, and the surface charge of niosomes without drug and loaded with drug is equal to -24.6 and -9.5 mV, respectively. The spherical morphology of niosomes was investigated using SEM-FE imaging and the sphericity of niosomes was confirmed using this method. Fourier transform infrared spectroscopy was used to investigate the functional groups of the constituent materials and possible changes during the preparation of niosomes. The loading of drugs and the analysis of the changes caused by the loading of drugs were investigated using this test method. The release rate of drugs by dialysis of prepared nano-systems was investigated and eva‎luated by using dialysis bag at 37 degrees Celsius and in three environments with different pH. In order to better investigate the release profile of the drugs in the acidic environment which has the highest release rate and also in the environment with pH conditions close to the blood plasma environment, it was drawn and analyzed. The best release for both drugs took place in an environment with acidic pH. In order to better investigate the release of drugs in acidic environment, the amount of release of drugs was also investigated in relation to time, which indicated a possible tension in the level of niosomes. Drug release kinetics was also investigated using mathematical models of drug release kinetics. The medicinal performance of nanosystems was eva‎luated using the MTT test against A549 and HDF cell lines. This test shows the good performance of nanosystems loaded with both drugs compared to A549 cell line.

نيوزوم , سورفكتانت غير يوني , سرطان ريه , كوركومين , ارلوتينيب

niosome , non-ionic surfactant , lung cancer , curcumin , erlotinib

Ali Emami

Dr. Ali Maleki