چكيده به لاتين
The direct use of anticancer drugs for patients may have inherent limitations of these drug molecules, including poor stability and dispersion in aqueous solution, low permeability in cell membranes, non-specific targeting, and uncontrolled drug release. Nanocarriers, especially those with targeting capabilities, stimuli-responsive properties, and drug-loading capabilities, hold great promise for improving these limitations. Organic covalent frameworks can be used as drug carriers with high loading efficiency, unique release function and low systemic toxicity. Hence, organic covalent frameworks are very attractive for tumor-targeted delivery of anticancer agent in vivo. In this research, we presented the steps of synthesis and specification of polymeric nanoparticles, covering covalent-organic frameworks (with porous structure). Polymeric nanoparticles have been synthesized using 1,3,5-tricarbohydrazide (BTCH) and tri-(4-formacyl-phenoxy)-1,3,5-tri-azine (TFPTA) in the presence of 6 M acetic acid catalyst. Then its application was used for drug delivery and pollutant absorption. In order to confirm the structure of synthesized polymer nanoparticles, several analyzes such as FT-IR, EDX, TGA, FE-SEM, BET, HRTEM and XRD were used.
