چكيده به لاتين
Among the cross-coupling reactions, the Suzuki and Heck reactions have received more attention due to the applications of related pharmaceutical products as active pharmaceutical ingredients. This research aimed to synthesize palladium magnetic nanocatalysis by thermal method on carbon substrate (Pd/g-C3N4/GO/Fe3O4) for use in the Suzuki reaction. For this purpose, graphene oxide, graphite carbon nitride, palladium, and iron oxide magnetic nanoparticles were mixed in water and ethanol. Next, the pH of the solvent was adjusted and was used ultrasonic. The reaction was transferred to the autoclave and placed inside it under suitable conditions. After the synthesis of the nanocatalyst, it was identified with FT-IR, XRD, FE-SEM, EDS, VSM and TGA analyses, and after confirming the synthesis, by adding palladium to examine the effect of the catalyst on the Suzuki reaction and other derivatives. To investigate the catalytic function, the nano catalyst was used in the Suzuki reaction, which effective parameters such as base, solvent, temperature and time was omptimzed by model reacton. The model reaction was defined with potassium carbonate as a base, water and ethanol as a solvent, 4 mg nanocatalyst, at 80 °C for 50 minutes, and then other bases, solvents and different temperatures were examined to find a best efficency. After optimization process, the best efficiency was obtained 94 % by water and ethanol as a solvent, potassium carbonate as a base, 6 mg nananocatalyst at 80°C for 50 minutes. Also, the possibility of reusing the catalyst was checked and result showed it can use for 3 time. Finally, the advantages of this research were, the short reaction time, the use of a green solvent (water/ethanol) and environmentally friendly, and the magnetic nanocatalysts, which causes the easy separation of the catalysts that can be recycled without the complicated methods, and separeted by magnet.
