فرزانه فرخي حاجي اباد

Until now, biocompatible and natural polymers have been highly efficient in the development of catalysis science and biomedical fields, especially in drug delivery, tissue engineering, and wound healing. These natural structures in the form of macromolecular hydrogel networks can act like soft tissue structures due to their hydrophilic nature, high sensitivity to physiological environments, sufficient flexibility and absorption capacity for a large amount of water and biological fluids. So far, the high efficiency and potential of natural polymers in the synthesis of a wide range of hydrogel-based scaffolds has been confirmed. Next to natural polysaccharides, natural proteins are one of the complex groups that have attracted the attention of scientists due to their significant potential in biomedical fields. Following these descriptions, in recent years, due to the unique physicochemical and attractive biomedical properties of nanomaterials, their synthesis and application have been exclusively expanded. In this research, nanocomposites based on hydrogels and natural polymer functionalized with silk fibroin were synthesized. In the first step, the characteristics of the structural features of the nanocomposite were eva‎luated. Then the cytotoxicity tests and compatibility with blood were checked by the methods mentioned below. Finally, the thermal properties of this nanocomposite were investigated by the heat-increasing method (hyperthermia) for anticancer applications.

هيدروژل , هايپرترميا

hydrogel , hyperthermia

Farzane Farrokhi Haji Abad

Dr. Ali Maleki