شادي بابائي دهنه سري

smart pH-sensitive nanocarriers are highly regarded among various stimulus-responsive systems in chemistry research.pH-sensitive nanocarriers exhibit stable behavior in neutral pH conditions in healthy tissues,while becoming unstable in acidic pH environment adjacent to cancer cells. This instability ultimately leads to the collapse of the nanocarriers structure and its subsequent release. Due to their small size and magnetic properties, magnetic nanoparticles have a strong tendency to aggregate. Therefore, surface modification of these particles is necessary to prevent aggregation and increase their circulation time in the bloodstream. In this research, surface modification of magnetite nanoparticles was conducated through several synthesis steps by adding SiO2 coating, APTES linker,THEIC, and EDTAD substances.Finally, to enhance the drug loading capacity of the nanocarrier, Ca ions were added to the carrier. Furthermore, the accuray of the obtained product was confirmed through FTIR, XRD, FE-SEM, and VSM analyses. Subsequntly, the absorption properties of the solutions were measured using UV-Vis spectroscopy at a wavelength of 522 nm.the results indicated that the processed nanoparticles of 94%, exhibited exceptional suitability as carriers for doxorubicin. This scientific study aimed to investigate the release behavior of a drug from modified nanoparticles in phosphate buffer solutions at two distinct pH levels:7.4(physiological pH)and5.the experiments was conducated at a temperature of 37 degrees Celsius to mimic physiological conditions. The study focused on eva‎luating the continuous release and sustained drug release from the nano carrier system. These findings contribute to the advancement of drug delivery systems, paving the way for more effective treatment options in the field of medicine.

نانو ذرات مگنتيت , دارورساني , دوكسوروبيسين , نانوحامل , اصلاح سطح

magnetite nanoparticles , drug delivery , doxorubicin , Nanocarrier , Surface modification

Shadi Babaei

Dr. Mohammad Ghorban Dekamin