حسين هدايتي

Presently, the significance of ascertaining the configuration of DNA in sundry disciplines such as pharmacology, genetics, agriculture, and numerous other fields is well-established. The identification of DNA's structure is instrumental in augmenting our cognizance of multiple genetic ailments, adopting efficacious treatment modalities, and comprehending human personality and evolution. Various approaches have been proposed to determine the structure of DNA, albeit most of these methods, besides their effectiveness, have drawbacks such as elevated costs, time-intensive protocols to procure results, and oftentimes, the outcomes were reported with a high degree of error. In an endeavor to surmount these limitations, scientists have discovered nanopores as a means to identify DNA's structure with superior precision and reduced time and cost in comparison to prior methods. When DNA traverses the nanopore, it exhibits a remarkably high velocity, thereby rendering the determination of the structure of individual nucleotides a formidable task. Numerous techniques have been suggested to address this challenge, such as augmenting the concentration of the ionic solution, varying the diameter of the nanopore, as well as modifying the number of DNA bases. In this investigation, we will explore the impact of an electric field on the transit of double-stranded DNA through the graphene nanopore, utilizing molecular dynamics simulation. Additionally, we will address the impact of this field on the water molecules within the cavity. The findings indicate that augmenting the strength of the electric field leads to heightened likelihood of DNA entrapment within the graphene cavity. Conversely, it also results in an acceleration of the DNA's transit through the cavity or a reduction in transit time. Correspondingly, the electric field triggers the accumulation of water molecules inside the cavity, which escalates with augmented field strength. The approach eva‎luated in this research may be utilized to raise the likelihood of DNA capture within graphene nanopore-based sequencing.

گرافن , ديناميك مولكولي , توالي دي ان اي

graphene , MD , DNA sequencing

Hossein Hedayati

Rouhollah Abdolvahab