ساناز جهانباني وشاره

Photothermal therapy using nanoparticles is one of the effective methods in cancer treatment that can be combined with other treatment methods including chemotherapy, gene therapy, and immunotherapy. In this thesis, the optical properties of various cubic-shaped nanoparticles such as silica, gold, and graphene-coated gold-silver alloy nanoshells and other two-dimensional materials are examined using dipolar approximation and effective medium theories. Then, using the bioheat transfer equations, the temperature distribution in kidney and lung tumor tissues and their surrounding environments in the presence of these nanoparticles and laser irradiation is calculated. Due to their high-temperature increase, the extinction efficiency and temperature distribution of cubic nanoparticles with two-dimensional coatings indicate that gold nanorods are suitable candidates for photothermal therapy applications. Additionally, we demonstrate that the plasmon resonance peak of surface-coated nanoparticles with two-dimensional materials can be easily adjusted within a wide range of biological windows by increasing the graphene shell's thickness or changing the nanoparticle aspect ratio. The presence of a graphene shell increases the stability of gold-silver nanoshells against oxidation, acid, and heat. The effects of laser intensity and the number of graphene layers on temperature increase in tumor tissue are investigated. Finally, to measure the effectiveness of the treatment, the likelihood of damage to tumor tissues and the surrounding environment in the photothermal therapy process is eva‎luated. The results of this research introduce a new group of nanoparticles with high efficiency and low side effects for lung and kidney cancer treatment using photothermal methods.

پديده تشديد پلاسموني , پنجره هاي بيولوژيكي , نانودرات مكعبي طلا-نقره و سيليكا , گرافين , دي كالكوژنيدهاي فلزات واسطه , خواص نوري و فتوترمال نانوذرات , معادلات انتقال زيست گرما

: Plasmonic resonance phenomenon , biological windows , cubic-shaped gold-silver and silica nanoparticles , Graphene , dichalcogenide transition metals , optical and photothermal properties of nanoparticles , bioheat transfer equations

Sanaz Jahanbani

Dr. Mehdi Esmaeilzade