سحر روزمه

The aim of this project is to achieve a biocompatible and biodegradable drug delivery system sensitive to pH with more release in acidic environments and controlled and long-term release for cancer treatment. In the present research work, two types of EDTAD-PMO and APS-TDU-PMO nanocarriers were synthesized and eva‎luated for drug delivery of the anticancer drug doxorubicin. Both were investigated using spectroscopic and microscopic methods such as FTIR, EDX, FESEM, TEM, XRD, TGA and BET analysis. Next, the results of measuring the absorption of the solutions by the ultraviolet-visible spectrometer (Vis-UV) at the wavelength of 479 nm showed that the synthesized nanocomposites, with a high percentage of loading, are suitable carriers for the drug doxorubicin. The drug release behavior was investigated in phosphate buffer saline at two pH values of 7.4 and 5 and at 37 degrees Celsius. The study of the absorption rate of the released drug solutions indicates the continuous release of the drug from the nanocarrier. Also, the MTT cytotoxicity test of APS-TDU-PMO nanocarrier showed that this nanocarrier has very low cytotoxicity and the doxorubicin-loaded nanocarrier APS-TDU-PMO@DOX has high cytotoxicity.

اورگانوسيليكاي مزو متخلخل دوره اي , داكسوروبيسين , نانو حامل , دارورساني , رهايش دارو

Periodic mesoporous organosilica , doxorubicin , Nanocarrier , drug delivery , Drug release

Sahar Roozmeh

Dr. Dekamin