چكيده به لاتين
Catalytic reactions of transition metals by converting accessible components into valuable and complex components have been noticed in the past decades. Today, these types of reactions have become a powerful path in organic chemistry due to their various and beneficial aspects, such as: high atom economy, compatibility with the environment, economic efficiency, etc. Among these types of reactions, the click reaction, which can lead to the formation of 1,2,3-triazoles, has been widely investigated. In the current study, the catalytic activity of cellulose-tannic acid in the presence of copper in the click reaction of alkyne/azide ring addition will be evaluated. The purpose of this evaluation is to investigate the possibility of using cellulose-tannic acid as a cheap, biodegradable, biocompatible, efficient, and easy-to-separate catalytic substrate. These compounds were first prepared in the late 20th century through the addition of azide to alkyne under harsh conditions. However, disadvantages such as low selectivity, difficulty in product separation, and high reaction temperature prevented its progress. In this situation, the use of catalysts was introduced as a favorable solution for the preparation of these compounds.
In this regard, heterogeneous catalysts are very important due to the possibility of easier separation. One of the most important substrates used in the preparation of catalysts are polysaccharides, which due to their unique biological characteristics, including antimicrobial, antitumor, and physicochemical properties such as abundance, availability, ability to gel, high number of functional groups, etc. .. have been investigated and are used in various fields such as biomedicine, drug delivery, food, water and wastewater treatment, catalyst, etc.
Considering the importance of the mentioned cases and in line with the performance of the research group in the past years, we decided to introduce the copper-based polysaccharide catalyst and check its efficiency in the click reaction and the preparation of triazole compounds.
