عرفان بهجت

The utilization of hydrogels in biomedical applications has been on the rise. This is attributed to their capability to create a moist wound environment and their amenability to composite with a diverse range of organic and mineral compounds. The aim of this research is to prepare a system with self-healing, pH-responsive, and excellent antibacterial properties with the ability to release the active agents in wound site. The polyvinyl alcohol/tannic acid/thyme-honey/ aloe vera (PVA/TA/thyme-honey/aloe vera) hydrogels were synthesized through a freeze-thaw method and fully characterized to eva‎luate their structural, chemical, morphological, antibacterial, and cytotoxicity properties. The hydrogels exhibit remarkable mechanical properties including tensile strength and compression resistance, along with viscoelastic behavior suitable for various body tissues. These hydrogels demonstrated the average healing efficiency of 81 percent within minutes, enabling them to endure mechanical stress commonly encountered in wound dressings. The study eva‎luates their swelling behavior and pH responsiveness, revealing their potential for maintaining a well-hydrated wound environment. Additionally, the release profiles of TA, thyme-honey, and aloe vera from hydrogels are investigated. Based on release data, 82, 100, and 88% of TA, thyme-honey, and aloe vera released from the hydrogels within 23 days. Moreover, the hydrogels demonstrated outstanding antibacterial efficacy, exhibiting an average inhibition rate exceeding 98% against both gram-positive and gram-negative bacteria. The bacterial inhibition in samples with a combination of thyme-honey and aloe vera exhibited a significant increase, reaching up to 99%, accompanied by a noteworthy enhancement in cell proliferation capacity. Overall, the nontoxic, antibacterial, and cost-effective fabricated hydrogels can be used in wound healing, tissue engineering, and drug delivery applications.

عسل , آلوئه‌ورا , خودترميم شونده , هيدروژل , پلي‌وينيل الكل , پاسخگو به pH , تانيك اسيد

honey , Aloe vera , Self-Healing , hydrogel , PVA , pH-responsive , Tannic acid

Erfan Behjat

Dr. Hamid Reza Rezaei - Dr. Maryam Tajabadi