چكيده به لاتين
The aim of this research was investigating the simulation of drug delivery systems of pegylated chitosan with beta-cyclodextrins. In this research, pegylated chitosan has been used to make a drug delivery substrate, and beta-cyclodextrin has been used as sites for the binding of metformin hydrochloride. FTIR, FESEM, UV-Vis, EDS, XRD, TGA, BET and Zeta potential analyzes have been used to investigate the structure, morphology, bond formation, drug loading and release. The cytotoxicity of the nanocarrier was evaluated using L929 cells (mouse fibroblasts) by the MTT method. In particular, chitosan, a natural polymer, stands out as a firstchoice material for hydrogels elaboration in biomedical, cosmetic, and health related applications, owing to its interesting properties including biocompatibility, biodegradability, antimicrobial capacity, and mucoadhesivity. Moreover, chitosan also allows drugs to absorb easier through biological barriers. pH-Responsive nanoparticles are regarded as an ideal candidate for antidiabetic drug. To achieve this goal, polyethylene glycol was grafted to the chitosan via sol-gel method and made a hydrogel. In the second step, beta-cyclodextrin was added as a carrier and citric acid as a cross-linking agent. Finally, metformin hydrochloride drug, as an effective substance for the treatment of type 2 diabetes, was loaded on a chitosanbased nanocarrier. The release of metformin hydrochloride drug was performed in vitro with pH 1/2 and 7/4, respectively. The final results showed that the synthetized nanocarrier is an effective and good substrate for delivering the metformin drug to the liver. In fact, the main goal of this research is to help treat type 2 diabetes by pH-sensitive drug delivery hydrogels.
