چكيده به لاتين
One of the most important challenges of the pharmaceutical industry is to ensure the optimal quality of the produced medicine without harming the health of patients. The presence of drug residues in other drugs, even in very small amounts, can have adverse and dangerous effects on the patient's health. Therefore, according to the new requirements of health protection organizations, it is necessary to develop sample preparation methods in order to increase the sensitivity and improve the detection limit in order to achieve accurate results. In this treatise, in five sections, the development and validation of new methods of microextraction coupled with high-performance liquid chromatography for measuring the amount of tamsulosin hydrochloride remaining in the samples obtained from the washing of drug production lines have been discussed. In the first part, the development and validation of a high-performance liquid chromatography method for the measurement of very small amounts of tamsulosin hydrochloride was carried out. The parameters affecting chromatography were optimized using the experimental design method. The detection limit and determination limit were 0.05 and 0.1 micrograms per ml and reproducibility of 0.14% was obtained. In development, the development and fabrication of a valid second solid-phase microarray in tubes coupled with liquid chromatography for the measurement of tamsulosin hydrochloride has been carried out. Many tools are economical and eco-friendly. In the third part, the electromembrane microextraction method coupled with liquid chromatography was investigated for analyte measurement. For this method, the detection limit was 0.05 ng/L, the repeatability was 0.67%, the significant reduction in analysis time, and the recovery percentage was about 93.3-97.6 for this method. The comparison of the experimental results with the standard liquid-liquid extraction method commonly used showed that the proposed method is a very suitable alternative. In the fourth part, the effectiveness of the liquid-liquid diffusion method for the supply of tamsulosin hydrochloride was investigated. The factors of the extraction device, including the diffusion rate and extraction solvent, sample pH and desalination effect are studied and optimized. Most importantly, this method has a higher recovery than the conventional standard method. In the last part, the efficiency of using magnetic polypyrrole to extract tamsulosin hydrochloride from water sample was studied. The optimization of the effective parameters was done using the test design method. High linearity range, good detection limit, short time, high recovery and selectivity, including The advantages of this method are. The higher accuracy of this method compared to the conventional method, besides the above advantages, confirms the possibility of replacing the proposed method in the pharmaceutical industry.
