رضا حسن زاده دوستكوه

In recent years, there has been a great interest in finding new molecules with environmental effects for Alzheimer's disease (AD). The selective loss of cholinergic neurons in AD leads to a lack of acetylcholineACh in certain areas of the brain that mediate learning and memory functions. Therefore, the primary approach for AD treatment is focused on increasing the level of acetylcholine, and this has made acetylcholinesterase (AChE) inhibitors to be considered as a suitable therapeutic target for the treatment of AD and the cause of dementia. Therefore, the development of new and effective methods for the synthesis of 1,2,3,4-tetrahydrocarbazole is significant. In organic chemistry, these synthetic compounds have a wide range of biological properties such as antibacterial, antifungal, antiviral, etc. In this research, the hybridized derivatives of 1,2,3,4-tetrahydrocarbazole along with the active pharmaceutical core of 1,3,4-oxadiazole were eva‎luated as potential anti-Alzheimer drugs. The structure of derivatives was confirmed using 1H NMR and 13C NMR spectroscopy results. Also, their binding affinity with AD therapeutic targets (AChE and BChE) was investigated using molecular docking (MD), these structures had high affinity with the catalytic sites of the respective enzymes.

)، مهاركننده بوتيريل¬كولين استراز , بيماري آلزايمر , مهاركننده¬¬ استيل¬كولين¬استراز

Alzheimer's disease , acetylcholinesterase inhibitor , butyrylcholinesterase inhibitor

reza hassanzade dostkoh

sharzad javanshir