پارسا باقرشاهي

Diabetes is one of the most common metabolic diseases in the world, resulting from increased glucose levels in the blood. Given the high number of patients, which is increasing daily, and the staggering costs associated with this disease, significant efforts have been made to control and treat this dangerous disorder. One of the promising approaches in the treatment of this disease is the design of drugs that can inhibit carbohydrate-degrading enzymes such as alpha-glucosidase, preventing the breakdown of sugars and their conversion to glucose, thereby inhibiting their absorption into the bloodstream. In this project, by utilizing heterocyclic compounds and using structures effective on the alpha-glucosidase enzyme, new derivatives of 7,6,5,4-tetrahydrobenzo-thiophene hybridized with 4,3-dihydroquinazoline have been synthesized as new inhibitors of the alpha-glucosidase enzyme, aiming for higher efficacy and fewer side effects compared to reference drugs. The formation of these derivatives has been confirmed through FT-IR, 1H-NMR, and 13C-NMR analyses. All synthesized compounds were eva‎luated for their inhibitory activity on the alpha-glucosidase enzyme, and efficacy was observed in all derivatives except for one; in several derivatives, the inhibitory effect was greater than that of the reference drug acarbose. Additionally, molecular docking was employed to observe the performance of these derivatives in interaction with the enzyme's active site.

ديابت , آنزيم آلفا گلوكسيداز , مهاركننده آنزيم آلفا گلوكسيداز

diabetes , alpha-glucosidase enzyme , alpha-glucosidase inhibitors

Parsa Baghershahi

Dr.shahrzad javanshir