چكيده به لاتين
In recent years, the development of cancer therapies based on nanotechnology has accelerated significantly, utilizing graphene, quantum dots, carbon nanotubes, dendrimers, liposomes, and nanoparticles as drug delivery agents. This rapid advancement is attributed to the remarkable properties and excellent drug loading capacity of these materials. Many of these nanomaterials can be synthesized from biodegradable substances that exhibit good biocompatibility, facilitating optimal size and efficient intracellular uptake or endocytosis.
To date, the preparation, fundamental properties, and applications of carbon dots have been extensively studied. However, there has been relatively little focus on carbon dot-based hydrogels. These hydrogels have garnered considerable attention in the field of biomedicine due to their low toxicity, cost-effectiveness, biodegradability, biocompatibility, and sustainability. Recent advancements in the release and distribution of drugs have leveraged carbon dot-based hydrogels in various biological applications, including drug release, wound healing, and cancer therapy. The use of biodegradable injectable hydrogels has attracted significant interest as they can provide sustained and controlled drug delivery to tumor sites with minimal adverse effects.
In this study, carbon dots were derived from natural sources, specifically a species of aquatic organisms, and utilized in the synthesis of hydrogels composed of carboxymethyl cellulose, polyvinyl alcohol, and borax. This injectable hydrogel was employed for the delivery of Doxorubicin in the body for the treatment of cancerous tumors.
