Synthesis an‎d Characterization of Nanostructured Metal–Organic Frameworks Based on Transition Metals an‎d Investigation of Their Applications in Energy Storage, Drug Delivery, an‎d Gas Adsorption

6/21/2026 12:00:00 AM

Metal–organic frameworks (MOFs), owing to their unique structural an‎d functional properties, have attracted significant attention in recent years across various scientific an‎d technological domains. In this study, diverse synthetic strategies were applied to MOF-74 to enhance its performance in three key applications: energy storage, smart drug delivery, an‎d selec‎tive gas adsorption. In the first part, a multimetallic MOF-74 structure containing manganese, cobalt, an‎d nickel (MnCoNiMOF-74) was synthesized in situ directly on a nickel foam substrate, aiming to improve its performance in energy storage systems. Electrochemical analyses revealed that the resulting porous structure, benefiting from synergistic interactions among metal ions, delivered a high specific capacitance of approximately 4390 mF/cm² an‎d demonstrated good cycling stability, highlighting its potential for use in advanced supercapacitor systems. In the second part, targeting the development of smart drug delivery platforms, two Zn-MOF-74-based nanostructures were synthesized using different anionic precursors (zinc acetate an‎d zinc nitrate) under ambient temperature conditions an‎d loaded with the anticancer drug doxorubicin (DOX). The nanostructure derived from zinc acetate (RA-MOF-74) exhibited a high drug loading efficiency of 96.5% an‎d a controlled release profile under acidic conditions, resulting in more effective anticancer activity an‎d lower cytotoxicity compared to the other sample. In the third part, a green an‎d rapid synthesis method was developed for MOF-74 (G-MOF-74) with controlled morphology to improve CO₂ adsorption performance. The synthesized structure, with its high surface area, achieved a remarkable adsorption capacity of 5.86 mmol/g at 298 K. Cyclic performance eva‎luation over 15 adsorption–desorption cycles showed less than 10% reduction in capacity, indicating good structural stability under operational conditions. The findings of this study demonstrate the significant potential of MOF-74-based structures for application in emerging technologies related to energy, biomedicine, an‎d environmental science. These results pave the way for the design of advanced metal–organic frameworks, particularly high-entropy MOFs, with multifunctional capabilities in future applications.

چارچوب‌هاي فلز-آلي , ماف-74 , ذخيره‌سازي انرژي , دارورساني , جذب گاز , Metal–Organic Frameworks , Metal–Organic Frameworks , MOF-74 , Energy Storage , Drug Delivery , Gas Adsorption

Metal–Organic Frameworks , MOF-74 , Energy Storage , Drug Delivery , Gas Adsorption

Amir Kazemi

Dr. Faranak Manteghi