Synthesis an‎d identification of Calcium-Zinc-Aluminum layered double hydroxides modified with pectin for medical applications

9/19/2025 12:00:00 AM

In this research, a magnetic nanocomposite based on pectin polymer was prepared along with the mineral composition of Calcium-Zinc-Aluminum layered double hydroxides as a drug carrier in a targeted drug delivery system for breast cancer treatment. The accuracy of the synthesis of this nanocomposite was checked an‎d confirmed by FT-IR, UV, XRD, FE-SEM, EDX, Mapping, BET, VSM, DLS an‎d zeta potential analyses. Layered double hydroxides were chosen for drug delivery due to their special layered structure, high surface-to-volume ratio, low toxicity, ease of synthesis, biocompatibility, increased solubility, an‎d stability. Pectin-based magnetic nanocomposite was added to the desired composition due to the presence of natural polymer an‎d targeted drug delivery due to the magnetic nature of the composition, biocompatibility an‎d biodegradability, stability, increased cell penetration an‎d controlled drug release. Doxorubicin was used as an injectable drug in this project. Doxorubicin is an anticancer drug that is used in the treatment of various types of cancer that affect the breast, bladder, ovary, thyroid, stomach, lung, bone, nerve tissue, muscles, joints an‎d soft tissues. Doxorubicin is also used in the treatment of Hodgkin lymphoma an‎d acute leukemia. The half-life of this injectable medicine is about 5 minutes, an‎d it can be said that it has a high absorption rate. Synthesis of nano drug carrier was done with the help of non-toxic solvents including water so that the effect of biocompatibility an‎d biodegradability of the compound would not be lost. The loading percentage of doxorubicin drug due to the presence of layered double hydroxides was calculated as a repeatable number above 90%, which is a desirable an‎d acceptable number for drug delivery work, an‎d especially to prevent the wastage of anticancer drug. Drug release in the simulated buffer environment of tumor tissue, due to the presence of selec‎ted polymer compound with controlled release property, was reported to be a favorable number an‎d above 40%. The results of the cytotoxicity test confirmed the possibility of using this compound as a suitable drug carrier for injection in the treatment of breast cancer; Cell viability for the final composite with loaded drug was reported to be 37% at a concentration of 500 μg/L (highest concentration) an‎d 90% at a concentration of 31.2 μg/L (lowest concentration).

هيدروكسيدهاي لايه اي دوتايي , نانوكامپوزيت ها , دارورساني , سرطان

layered double hydroxides , nanocomposites , drug delivery

Sadegi

Dr. akbarzadeh _ Dr. khanlarkhani