The improvement of drug delivery to lungs from air inhalation by utilization of nano drugs an‎d numerical simulation of lung tissue

9/15/2026 12:00:00 AM

With the recent increase in lung diseases, especially with the onset of the coronavirus pan‎demic, the design of a highly efficient an‎d optimal targeted drug delivery system for the lungs is crucial in inhaler-based delivery systems. This study aimed to design a magnetic field-assisted targeted drug delivery system to the lungs using three types of metal–organic frameworks (MOFs) an‎d nanoliposomes. The optimization of the system was based on three main parameters: the surface density of the nanocarriersʹ (NCs) adherence to each of the lung branches, the amount of drug transferred to each branch, an‎d the toxicity based on the rate of nanocarrier delivery to the branches. The study investigated the effect of increasing the diameter of the drug carriers an‎d the amount of drug loaded onto the NCs in improving drug delivery to targeted areas of the lung. Results showed that the presence of a magnetic field significantly increased the adhesion of NCs to the targeted branches. The application of a magnetic field an‎d the type of drug carrier had a significant effect on drug delivery downstream of the lung an‎d reduced drug toxicity. The study found that Fe3O4@UiO-66 (iron-oxide nanoparticle attached to the surface of UiO-66, a type of MOF) an‎d Fe3O4@PAA/AuNCs/ZIF-8 carriers, (iron-oxide nanoparticle attached to a hybrid structure composed of three different materials: poly (acrylic acid) (PAA), gold nanoclusters (AuNCs), an‎d zeolitic imidazolate framework-8 (ZIF-8)), had the greatest drug delivery rate in diameters above 200 nm an‎d less than 200 nm, respectively.

چارچوب هاي آلي فلزي , دارورساني هدفمند , نانوذرات , ميدان مغناطيسي

Metal-organic frameworks , Targeted drug delivery , Nanocarriers , Magnetic field

Mohammad Erfan Maleki

Dr. Sasan Asiaei