مهدي كريمي

Benzodiazepines are considered a vital class of heterocyclic compounds due to their extensive pharmaceutical applications. However, their synthesis is often associated with challenges such as multiple steps, harsh reaction conditions, an‎d difficulty in catalyst separation. In this research, a novel heterogeneous magnetic nanocatalyst with a core-shell structure, Fe₃O₄@ZrO₂/UiO-66-NO₂, was designed an‎d successfully synthesized for the efficient an‎d one-pot synthesis of 1,5-benzodiazepine derivatives. This catalyst was prepared through a multi-step method involving the preparation of the Fe₃O₄ magnetic core, coating it with a layer of ZrO₂, an‎d finally the growth of the UiO-66-NO₂ type Metal-Organic Framework (MOF) on its surface. The structure, morphology, magnetic properties, an‎d thermal stability of the synthesized nanocatalyst were thoroughly investigated an‎d confirmed using various techniques including X-ray Diffraction (XRD), Fourier-Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), Vibrating Sample Magnetometry (VSM), BET analysis (porosimetry), an‎d Thermal Analysis (TGA/DTA). The catalytic activity of the synthesized material was eva‎luated in a one-pot, three-component condensation reaction between o-phenylenediamine, 2-acetylpyridine, an‎d various benzaldehyde derivatives. The optimal reaction conditions, including temperature, catalyst amount, an‎d solvent volume, were determined using Response Surface Methodology (RSM) an‎d Box-Behnken Design (BBD). The results showed that the Fe₃O₄@ZrO₂/UiO-66-NO₂ nanocatalyst exhibits very high catalytic activity, producing the desired products with excellent yields under optimized conditions. This catalyst offers significant advantages such as easy separation using an external magnetic field, reusability for several cycles without a significant decrease in activity, mild reaction conditions, an‎d high efficiency. This research introduces an innovative, efficient, an‎d green approach for the synthesis of important pharmaceutical compounds.

نانوكاتاليست مغناطيسي , 1٬5-بنزود يازپين (1,5-بنزوديازپين)

Magnetic nanocatalyst , 1,5-Benzodiazepine

Mahdi Karimi

Ali Maleki