مهسا عابدي كردكندي

Click chemistry, as an efficient an‎d green approach for the synthesis of heterocyclic compounds—particularly 1,2,3-triazole derivatives—has gained a prominent position in medicinal chemistry an‎d advanced material design. Furthermore, the development of magnetic heterogeneous catalysts has attracted considerable attention due to their advantages such as high stability, recyclability, ease of separation, an‎d compatibility with the principles of green chemistry. In this study, a novel magnetic catalyst based on Fe₃O₄@SiO₂ nanoparticles functionalized with guanidine was synthesized an‎d thoroughly characterized using spectroscopic an‎d microscopic techniques. The presence of guanidine groups on the nanoparticle surface improved the catalytic properties, including enhanced yield, selec‎tivity, an‎d reaction rate. The catalytic performance of this material was examined in click chemistry reactions, an‎d the results revealed that the synthesized catalyst efficiently produced 1,2,3-triazole derivatives under mild conditions an‎d with remarkable yields. Moreover, the catalyst maintained its activity after several consecutive reuse cycles, indicating desirable stability an‎d recyclability. Overall, the findings of this research demonstrate that the guanidine-based magnetic catalyst can serve as an efficient, robust, an‎d environmentally friendly option for the synthesis of triazole compounds.

هتروسيكل , تري آزول , واكنش كليك , كاتاليست , گوانيدين

Heterocycle , Triazole , Click reaction , Catalyst , Guanidine

Mahsa Abedi

Shahrzad Javanshir