Synthesis, Identification, an‎d Application of Zeolite, SBA, an‎d Inorganic Polymer-Based Porous Polymer Nanocomposites in Targeted Drug Delivery an‎d Cancer Treatment

10/22/2026 12:00:00 AM

: Cancer is one of the leading causes of mortality in industrialized countries. In recent years, advancements in science have led to early diagnosis an‎d an increase in treatment options, resulting in a reduction in mortality rates. Due to the rise of drug-resistant cancers an‎d the severe side effects of traditional treatments, there is an ongoing need to search for innovative an‎d more effective therapies. This research eva‎luates targeted drug delivery via injection, utilizing a magnetic polymer nanocomposite base made of the mineral polymer polydimethylsiloxane, chitosan, an‎d the drug doxorubicin, which is widely used in breast cancer treatment. The polydimethylsiloxane polymer was used due to its favorable properties, such as enhanced drug release from the nanocomposite, improved drug characteristics, an‎d its anticancer properties. Additionally, the non-toxic structures of zeolite an‎d SBA, due to their porosity an‎d high biocompatibility, increase the drug loading capacity in the nanocomposite substrate. Furthermore, the beneficial properties of the natural polymer chitosan enhanced the efficiency of the nanocomposites. The changes made in the nanocomposite system using folic acid showed satisfactory results in the targeted delivery of this nanocomposite to cancer cells. The results obtained in this research were eva‎luated through chemical an‎d instrumental tests such as FT-IR, XRD, BET, DLS, Fe-SEM, EDX, an‎d zeta-potential, as well as the non-toxicity of the synthesized nanostructures assessed by the MTT colorimetric assay. Drug loading of doxorubicin in the synthesized nanocomposites at a ratio of 1:5 resulted in favorable outcomes. In the zeolite nanocomposite, the drug encapsulation rate was 99%, an‎d in the SBA nanocomposite, this value was reported as 98%. The results of the anticancer drug release in simulated body environments were observed to be approximately 50% in the acidic tumor environment an‎d about 5% in the relatively neutral blood environment after 96 hours. This trend was also investigated in the SBA nanocomposite, where the results showed a release rate of about 40% in the acidic environment an‎d 11% in the blood. Based on the results obtained, targeted drug delivery through folic acid an‎d magnetic nanoparticles, as well as controlled release in acidic environments, has proven to be effective.

دارورساني هدفمند، نانوذرات مغناطيسي، سرطان سينه، كيتوسان، پلي دي متيل سيلوكسان، زئوليت، SBA فوليك اسيد

Targeted drug delivery, magnetic nanoparticles, breast cancer, chitosan, polydimethylsiloxane, zeolite, SBA, folic acid

Sama Bakhtiari

Dr. Alireza Akbarzadeh