چكيده
Abstract:
Cyanohydrins and their trimethylsilyl ethers are key building blocks
for the one-step synthesis of many biologically active compounds.
On the other hand, as a consequence of the necessity to minimize the
amount of toxic waste and by-products from chemical processes, there is
a need to develop new and more environmentally friendly synthetic
methods in which fewer toxic substances are used. Nowadays in the
development of new syntheses, ecological points of view must also be
taken into consideration and apportioned due to importance in the
assessment of viability. Many organic solvents are flammable, toxic, and
volatile compounds or hazardous air pollutants. Therefore, solvent-free
synthesis is highly becoming more popular, especially in industry,
because it may be both more environmentally benign and more
economically feasible.
We have developed a new efficient and mild catalysts which operate
under solvent-free conditions (is a very active research effort).
Potassium Phethalimide was found to be an effective and easily
accessible Lewis basic catalyst for the facile cyanosilylation of carbonyl
compounds in high to quantitative yields under solvent-free conditions at
room temperature.
